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1992 …2022

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Research Interests

Cancer cells exhibit altered metabolism including high demand for cholesterol for rapid cell proliferation. Scavenger receptor BI (SR-BI) is a HDL receptor. It mediates the uptake of cholesterol from HDL. Recent studies including ours indicate that SR-BI is highly expressed in breast cancer and the levels of SR-BI expression are negatively correlated with cancer survival. We hypothesize that SR-BI-mediated cholesterol uptake from HDL provides cholesterol for cancer cell growth, and blocking SR-BI-mediated cholesterol uptake from HDL inhibits cancer cell proliferation, which may provide a novel approach for cancer therapy. We currently use a combination of molecular, cellular and genetically manipulated animal models to test our hypothesis.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Osaka Uni.

1994

Master of Science, Shandong University

1985

Bachelor of Science, Shandong University

1982

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