Calculated based on number of publications stored in Pure and citations from Scopus
1989 …2023

Research activity per year

Personal profile

Research Interests

The primary research interest of our laboratory is to understand how cell adhesion molecules or receptors contribute to cancer development, progression and metastasis, and to evaluate the potential of these molecules as candidate biomarkers or therapeutic targets for the early detection, diagnosis and treatment of such malignant diseases. Our recent projects involve the functional analyses of heterodimeric adhesion receptors, named laminin-binding (LB) integrins (i.e., alpha3/beta1, alpha6/beta1 and alpha6beta4, and their associated tetraspanin CD151, in human breast, ovarian and skin cancer as well as mammary gland development. In these studies, we have attempted to assess tumor onset and metastasis as well as underlying mechanisms by using gene-targeted mice, transgenic animal models and 3D cell culture model. Our current studies focus on the following functional aspects of these molecules and their associated protein complexes:

• Signaling roles in tumor cell proliferation, motility and invasion in multiple types of human carcinomas.
• Genetic and transcriptional regulation of the niches and homeostasis of normal or malignant epithelial stem/progenitor cells.
• Control of the reciprocal interactions between tumor cells and their microenvironments (e.g., remodeling of extracellular matrices and infiltration of stroma cells).
• Transcriptional regulation of cell-cell contacts and Epithelial-Mesenchymal Transition (EMT) during tumor progression.
• Molecular contribution to late-stage tumor metastasis, e.g., tumor cell extravasation through vasculature or colonization at distant sites.
• Collaboration with diverse oncogenic or pro-malignant pathways, including those driven by Receptor Tyrosine Kinases (e.g., EGFR and ErbB2), focal adhesion kinase (FAK) and small GTPases (Rac1, Rho A and Cdc42), as well as canonical Wnt signaling.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Post Doctoral Fellow, Cancer Treatment and Research Foundation Manitoba, Canada

1996

Doctor of Philosophy, University Of Manitoba

1994

Master of Science, University Of Manitoba

1989

Bachelor of Science, Shanghai University

1985

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