Calculated based on number of publications stored in Pure and citations from Scopus
1977 …2024

Research activity per year

Personal profile

Research Interests

Our research interest is to understand the molecular mechanisms of the protective immunity to infectious agents.  This includes the effects of the infections on development of other diseases such as cancer.  We are using murine models of infection with Toxoplasma gondii, an obligate intracellular protozoan parasite.  T. gondii establishes a chronic infection by forming cysts preferentially in the brain, and one third of human population worldwide is estimated to be chronically infected with this parasite.  Recent epidemiological studies demonstrated that T. gondii infection is associated with a 1.8-fold increase in the risk of brain cancers, and that brain cancer mortality rates increase with T. gondii seroprevalence.  These evidences strongly suggest that T. gondii contributes to development of brain cancers and mortality associated with the cancers.  Therefore, it is important to prevent infection with this parasite in order to reduce a risk of developing brain cancers and the cancer-associated mortality. 

Our research has recently been focused on analyzing the molecular mechanisms of the protective immune responses to T. gondii, especially in the brain and on applying the knowledge obtained from these studies to improve prevention and treatment of the infection.  These projects have an excellent potential to provide valuable information for prevention of brain cancers.  In addition, I have considerable experience in analyzing the antitumor effects of immunomodulatory agents using murine models of lung carcinoma and lymphoma. 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, The UniversityOf Tokyo

1982

Bachelor of Science, The UniversityOf Tokyo

1976

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