Projects and Grants per year
Personal profile
Research Interests
Our research interest is to understand the molecular mechanisms of the protective immunity to infectious agents. This includes the effects of the infections on development of other diseases such as cancer. We are using murine models of infection with Toxoplasma gondii, an obligate intracellular protozoan parasite. T. gondii establishes a chronic infection by forming cysts preferentially in the brain, and one third of human population worldwide is estimated to be chronically infected with this parasite. Recent epidemiological studies demonstrated that T. gondii infection is associated with a 1.8-fold increase in the risk of brain cancers, and that brain cancer mortality rates increase with T. gondii seroprevalence. These evidences strongly suggest that T. gondii contributes to development of brain cancers and mortality associated with the cancers. Therefore, it is important to prevent infection with this parasite in order to reduce a risk of developing brain cancers and the cancer-associated mortality.
Our research has recently been focused on analyzing the molecular mechanisms of the protective immune responses to T. gondii, especially in the brain and on applying the knowledge obtained from these studies to improve prevention and treatment of the infection. These projects have an excellent potential to provide valuable information for prevention of brain cancers. In addition, I have considerable experience in analyzing the antitumor effects of immunomodulatory agents using murine models of lung carcinoma and lymphoma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, The UniversityOf Tokyo
1982
Bachelor of Science, The UniversityOf Tokyo
1976
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Collaborations and top research areas from the last five years
Projects & Grants
- 18 Finished
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Tumor Microbiota-derived Signaling in Colon Carcinogenesis and Cancer Treatment
Alam, M. (PI), Evers, B. M. (CoI), Gao, T. (CoI) & Suzuki, Y. (CoI)
6/1/22 → 5/31/23
Project: Research project
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Gender-Dependent Innate IL-10 Production as a Key Pathogenic Factor to Promote Toxoplasmic Encephalitis
Suzuki, Y. (PI)
National Institute of Allergy and Infectious Diseases
5/1/18 → 4/30/21
Project: Research project
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Microenvironment and Arsenic Lung Tumorigenesis
Chen, G. (PI), Marti, F. (CoI) & Suzuki, Y. (CoI)
National Institute of Environmental Health Sciences
9/30/17 → 8/31/24
Project: Research project
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Microbially Generated Protons Mediate Interkingdom Host-Microbiome Cross-Talk and Maintain Intestinal Homeostasis via Reciprocal Functions of Two Proton-Sensing GPCRs
Alam, M. (PI), Barrett, T. (CoI), Evers, B. M. (CoI), Gao, T. (CoI) & Suzuki, Y. (CoI)
National Institute Diabetes & Digestive & Kidney
8/1/17 → 5/31/22
Project: Research project
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A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Deficiencies of Inducible Costimulator (ICOS) During Chronic Infection with Toxoplasma gondii Upregulate the CD28-Dependent Cytotoxicity of CD8+ T Cells and Their Effector Function Against Tissue Cysts of the Parasite
Mani, R., Balu, K. E. & Suzuki, Y., Dec 2024, In: Cells. 13, 23, 1998.Research output: Contribution to journal › Article › peer-review
Open Access -
The Absence of CXCL10 Activity Does Not Affect the Capability of CD8+ T Cells to Migrate and Eliminate the Tissue Cysts of Toxoplasma gondii from the Brains of Chronically Infected Mice
Mani, R. & Suzuki, Y., Nov 2024, In: Microorganisms. 12, 11, 2172.Research output: Contribution to journal › Article › peer-review
Open Access -
Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infection
Mani, R., Abdelaziz, M. H., Ochiai, E., Sa, Q., Fox, B. A., Bzik, D. J. & Suzuki, Y., 2023, In: Frontiers in Immunology. 14, 1272221.Research output: Contribution to journal › Article › peer-review
Open Access -
IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii
Suzuki, Y., Lutshumba, J., Chen, K. C., Abdelaziz, M. H., Sa, Q. & Ochiai, E., 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 1110508.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations