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24-MULTI-65-TB-PMC (TORL123-001): A Phase 1, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer

Grants and Contracts Details

Description

24-MULTI-65-TB-PMC (TORL123-001): A Phase 1, First in Human, Dose-Escalation Study of TORL-1-23 in Participants With Advanced Cancer Primary: 1. To characterize the safety, tolerability, and DLTs and to determine the MTD and the RP2D of TORL-1-23 administered as monotherapy in participants with advanced cancer 2.To characterize the safety, tolerability, and the RP2D of TORL-1-23 administered in combination with bevacizumab Secondary: 1. To characterize the PK of TORL-1-23 and its breakdown products (MMAE and TORL-1-23MAB) 2. To assess the preliminary antitumor activity of TORL-1-23 in participants with advanced cancer 3. To assess the immunogenicity of TORL-1-23
StatusActive
Effective start/end date2/19/25 → 2/19/27

Funding

  • Translational Research in Oncology: $104,467.00

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