Grants and Contracts Details
Prospective, Single-Center, Randomized, Triple-Blinded, Placebo-Controlled study of IL-1RA Treatment in Patients with Acute ACL Tear and Painful Effusions Primary Objective: To assess the efficacy of using IL-1ra and knee arthrocentesis to alleviate inflammation related knee pain and improve patient-reported outcomes (PRO) following ACL rupture. Secondary Objectives: 1. To determine if intra-articular IL-1ra therapy improves levels of a panel of inflammatory, meniscus and cartilage metabolism, and oxidative stress biomarkers as measured in synovial fluid, serum and urine from patients immediately after ACL injury (baseline, 2, weeks after injury and at 1 and 2 years after surgery). 2. To assess if MRI T1rho changes correlate with synovial biomarker levels and show predictive value for the overall subject patient outcome at 2 years
|Effective start/end date||12/1/17 → 10/31/20|
- Arthritis Foundation: $224,475.00
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