Admin Supplement: A Multiscale Multimodal Diffuse Optical Device for Early Diagnosis of Preclinical Alzheimer's Disease

Grants and Contracts Details


Hypothesis #1: The magnitudes of brain functional activations during memory-activation tasks, quantified by DSCFO measurements of StO2, CBF and CMRO2, will be greater in cognitively normal APOE4 carriers (at risk for AD) compared to those in age-matched healthy controls. Specific Aim #1: Conduct a randomized, controlled, single-blind (investigator), biomarker validation trial of DSCFO measurements in older subjects with APOE4 (n = 15) vs. Controls without APOE4 (n = 15). The prototype DSCFO device/probe and algoriths for data analysis will be refined, optimized, and calibrted against the established NIRS/DCS technique for cerebral monitoring in adult human subjects with thicker scalps and skulls compared to small rodents and human infants. Expected Outcomes/Impacts: We expect to provide a noninvasive (using low-power NIR lights), low-cost (
Effective start/end date9/1/191/31/22


  • National Institute of Child Health and Human Develop


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