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Description
Hypothesis #1: The magnitudes of brain functional activations during memory-activation tasks, quantified by DSCFO measurements of StO2, CBF and CMRO2, will be greater in cognitively normal APOE4 carriers (at risk for AD) compared to those in age-matched healthy controls.
Specific Aim #1: Conduct a randomized, controlled, single-blind (investigator), biomarker validation trial of DSCFO measurements in older subjects with APOE4 (n = 15) vs. Controls without APOE4 (n = 15). The prototype DSCFO device/probe and algoriths for data analysis will be refined, optimized, and calibrted against the established NIRS/DCS technique for cerebral monitoring in adult human subjects with thicker scalps and skulls compared to small rodents and human infants.
Expected Outcomes/Impacts: We expect to provide a noninvasive (using low-power NIR lights), low-cost (
Status | Finished |
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Effective start/end date | 9/1/19 → 1/31/22 |
Funding
- National Institute of Child Health and Human Develop
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Projects
- 1 Finished
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A Low-cost Compact Diffuse Speckle Contrast Flow-oximeter for Neonatal Brain Monitoring
Yu, G. (PI), Abu Jawdeh, E. (CoI), Bada, H. (CoI), Huang, C. (CoI) & Huang, C. (Former CoI)
National Institute of Child Health and Human Develop
2/10/18 → 1/31/22
Project: Research project