Projects and Grants per year
Grants and Contracts Details
Description
This is a proposal for a 5-year Alzheimer's Disease Core Center (ADCC) at the University of Kentucky's
Sanders-Brown Center on Aging. The application consists of the Administrative, Clinical, Biostatistics and
Data Management, Neuropathology, Education and Information Transfer Cores, and two pilot projects. The
UK ADC has developed a strong program in the clinical, neuropathological, educational and research
aspects of AD that serves as a resource for the university, community, state, and region for the past twenty
years. The major goals of the UK ADC are to: a) provide clinical data, serum, plasma, buffy coats and CSF
from thoroughly evaluated, longitudinally followed, normal control subjects, AD and non-AD dementing
disorders, and postmortem material from these subjects to investigators of AD and aging at UK and to
national and international investigators, b) continue longitudinal investigation of presymptomatic AD, mild
cognitive impairment, early AD, mixed dementias and other dementias, and normal brain aging with autopsy
as an end point; c) develop new research initiatives and attract new investigators to research in
neurodegeneration and aging; d) place emphasis on serving minorities and involving them in research; and
e) participate in multicenter efforts, including NACC, ADCS, ADNI, and others. The Clinical Core will
evaluate and longitudinally follow 500 subjects in the Normal Control (BRAiNS) Clinic and 200 patients with
AD and other dementi as in the Dementia Research Clinic - all with prearranged autopsies. This core will
maintain a satellite clinic for African Americans in north Lexington in conjunction with an Administration on
Aging grant for education of minorities about dementing disorders. The Neuropathology Core provides short
postmortem interval brain specimens, CSF, and synaptosomes from longitudinally followed normal, MCI,
early and late AD patients, and non-AD dementias to investigators and maintains a tissue bank. The
Biostatistics and Data Management Core manages data sets from the other Cores, prepares the Uniform
Data Set and the Minimum Data Set for submission to the NACC, and provides statistical design and
analysis. The Education and Information Transfer Core assists with recruiting control and dementia
subjects, provides research and clinical training for investigators and healthcare professionals, and
disseminates information to the lay public.
Status | Finished |
---|---|
Effective start/end date | 7/15/06 → 6/30/10 |
Funding
- National Institute on Aging: $1,324,074.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 7 Finished
-
-
Alzheimer's Disease Center Core C
Kryscio, R., Mendiondo, M. & Schmitt, F.
7/15/06 → 6/30/10
Project: Research project
-
Alzheimer's Disease Center Pilot: Compensatory Gene Expression Changes in Nondemented Individuals with Alzheimer Disease Neuropathology
Head, E. & Blalock, E.
7/15/06 → 6/30/10
Project: Research project