Projects and Grants per year
Grants and Contracts Details
Description
The aim of the present proposal is to acquire preliminary data on potential functional neuroanatomic
markers of mild Alzheimer's disease (AD). We propose to compare functional activation patterns in
approximately 25 mildly demented individuals and 25 carefully matched control subjects during the
performance of episodic memory encoding and appropriate baseline tasks while functional
magnetic resonance imaging (fMRI) is performed. Region of interest (ROI) analyses will compare
relative activation patterns in targeted frontal, and temporal lobe regions known to be involved in
episodic memory encoding in normal individuals. In addition, whole-brain activation maps will be
generated to explore potential differences in other regions. Potential differences in activation will be
explored along lines of (1) magnitude; (2) spatial extent; and (3) temporal characteristics of
hemodynamic response functions to examine potentially subtle differences in the timing of
activation. Completion of this research will provide preliminary data concerning functional
neuroanatomic changes accompanying episodic memory impairment in mild AD. In addition, the
proposed project will serve as a foundation for the development of subsequent fMRI paradigms
intended to characterize subjects at risk, to differentiate normal age-related memory changes from
prodromal dementia, and to monitor the effects of therapy as adjuncts to neuropsychological and
clinical assessments.
Status | Finished |
---|---|
Effective start/end date | 9/30/85 → 7/14/06 |
Funding
- National Institute on Aging
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 1 Finished
-
Alzheimer's Disease Research Center - Year 21
Markesbery, W. (PI), Cooper, G. (CoI), Danner, D. (CoI), Jicha, G. (CoI), Kryscio, R. (CoI), Mendiondo, M. (CoI), Scheff, S. (CoI), Schmitt, F. (CoI), Smith, C. (CoI), Stiles, N. (CoI), Wekstein, D. (CoI) & Wilson, D. (CoI)
9/30/85 → 7/14/06
Project: Research project