Projects and Grants per year
Grants and Contracts Details
Description
Supplemental funds are requested to conduct a highly interdisciplinary study with
a mouse model that mimics metabolic syndrome. Past studies by us and others have
demonstrated that the LDL-R deficient mouse being fed a "Western" high-fat diet will
develop symptoms of metabolic syndrome (1-3). Our laboratory also has reported that
dietary fat (high corn oil feeding) interacts with PCBs to induce changes in lipid
metabolism in mice deficient in the LDL receptor (4).
The aim ofthis proposal is to study the hypothesis that high-fat or high-caloric
diets will contribute to symptoms of metabolic syndrome and thus worsen or
accelerate the cardiovascular risk associated with exposure to persistent organic
pollutants such as PCBs.
The metabolic syndrome is characterized by many cardiovascular risk factors,
which include abdominal obesity, with a state of abnormal glucose and lipid metabolism
and chronic inflammation. Endothelial dysfunction is common in the metabolic
syndrome and is associated with increased risk for vascular diseases (5,6). Our long-term
goal is to understand nutritional intervention and prevention therapies, which will prevent
risk factors of the metabolic syndrome and thus heightened susceptibility to
environmental insults and pathology of vascular diseases.
Status | Finished |
---|---|
Effective start/end date | 4/7/97 → 3/31/08 |
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Projects
- 1 Finished
-
Nutrition and Superfund Chemical Toxicity
Hennig, B. (PI), Bachas, L. (CoI), Bhattacharyya, D. (CoI), Cassis, L. (CoI), Daugherty, A. (CoI), Daunert, S. (CoI), Everson, W. (CoI), Gaetke, L. (CoI), Kyprianou, N. (CoI), Lodder, R. (CoI), Ormsbee, L. (CoI), Ozcan, S. (CoI), Stromberg, A. (CoI), Toborek, M. (CoI), Wei, Y. (CoI), Zhu, H. (CoI) & Gavalas, V. (Former CoI)
National Institute of Environmental Health Sciences
4/1/97 → 3/31/08
Project: Research project