AREN03B2: Renal Tumors Classification, Biology, and Banking Study

Abstract Primary Objectives To classify patients with renal tumors by histological categorization, surgicopathological stage, presence of metastases, age at diagnosis, tumor weight and loss of heterozygosity for chromosomes 1p and 16q, to thereby define eligibility for a series of therapeutic studies. To maintain a biological samples bank to make specimens available to scientists to evaluate additional potential biological prognostic variables and for the conduct of other research by scientists. Secondary Objectives To monitor outcome for those patients who are not eligible for a subsequent therapeutic study. To describe whether the pulmonary tumor burden correlates with outcome in Stage IV patients. To describe the sensitivity and specificity of abdominal computed tomography (CT) by comparison with surgical and pathologic findings for identification of local tumor spread beyond the renal capsule to adjacent muscle and organs, lymph node involvement at the renal hilum and in the retroperitoneum, preoperative tumor rupture and metastases to the liver. To compare the sensitivity and specificity of preoperative abdominal CT and MRI for the identification and differentiation of nephrogenic rests and Wilms tumor in children with multiple renal lesions. To correlate the method of conception (natural versus assisted reproductive technology) with the development of Wilms tumor. To evaluate the frequency of INI1 mutations in renal and extrarenal malignant rhabdoid tumor of the kidney and to determine the incidence of germline and inherited versus somatic mutations to Background: Outcomes Treatment of Wilms tumor has been determined solely on the basis of histopathological classification (favorable versus anaplastic or unfavorable histology)1 and on surgical stage.2 Long term outcomes from National Wilms Tumor Study – 4 (NWTS-4), as indicated in Table 1, reveal that the current classification schema is imperfect in identifying many patients who develop recurrent disease. A primary goal of the COG Renal Tumor Committee is to refine the current classification schema to better stratify patients into risk-appropriate treatment groups. To this end, AREN03B2, the first Renal Tumor Classification and Banking Protocol, will incorporate molecular biological data obtained from NWTS-5 into the classification schema.