Grants and Contracts Details
Description
The proposed Center will be in the area of Fetal Programming
as a mechanism promoting the development of obesityinduced
cardiovascular diseases in adult offspring
(Figure 1 ). The research problem to be addressed is an
extension of the NIH-funded COBRE in Obesity and
Cardiovascular Diseases (atherosclerosis, hypertension,
thrombosis), and related to the primary research focus
within the GCNS. In the NIH-funded COBRE, investigators
use high fat (HF) feeding in adult mice as a model common
to all projects to identify mechanisms linking diet-induced
obesity to cardiovascular diseases. We propose to
complement and extend these studies by recruit of a faculty
member with interests in fetal programming through
nutritional manipulation (e.g., over or under nutrition, dietary
salt content, dietary fat or cholesterol content) during
development as a mechanism increasing susceptibility to
obesity and cardiovascular diseases during adulthood.This powerful approach, supported by specialized research
cores for analysis of obesity and cardiovascular diseases,
can be used to contrast effects
of nutritional manipulation (e.g., high fat feeding) during
development to the level of disease induced by feeding adult offspring a high fat diet. We provide below the
rationale for the study of fetal programming as a mechanism promoting obesity-induced cardiovascular
diseases.
Status | Finished |
---|---|
Effective start/end date | 9/30/09 → 8/31/13 |
Funding
- National Heart Lung and Blood Institute: $1,110,233.00
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