Grants and Contracts Details
Description
To be completed by Diabetes Action Research and Education Foundation:
No. ________________
Date _______________
Appendix 2 - PROJECT SUMMARY IN LAY TERMS
Project Title: Asprosin-Ptprd receptor signaling: Effects on pancreatic β cell function and therapeutic
strategies for diabetes treatment.
Applicant: Ila Mishra
Summary:
The newly discovered hormone, asprosin, increases blood glucose levels, stimulates appetite, impairs
insulin secretion and inhibits glucose uptake by the muscles, thereby exacerbating type 2 diabetes.
This study aims to investigate the role of Ptprd receptor, and its small molecule inhibitor in asprosin
mediated effects on beta cell function. Patients with diabetes typically exhibit elevated asprosin levels,
while genetically reducing asprosin levels confers protection against diabetes. This same protection
can be achieved by using a drug called an antibody that inhibits asprosin, presenting a promising
therapeutic avenue. Our prior research demonstrated decreased appetite and blood glucose levels in
diabetic mice following treatment with an asprosin-inhibiting antibody. However, the potential of this
antibody to enhance pancreatic function and insulin sensitivity remains unexplored, a gap this grant
proposal seeks to address. This investigation marks a crucial step forward in the development of novel
drug for diabetes management.
Status | Active |
---|---|
Effective start/end date | 1/1/25 → 12/31/25 |
Funding
- Diabetes Research and Education Foundation: $50,000.00
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