Asprosin-Ptprd Receptor Signaling: Effects on Pancreatic Beta Cell Function and Therapeutic Strategies for Diabetes Treatment

Grants and Contracts Details

Description

To be completed by Diabetes Action Research and Education Foundation: No. ________________ Date _______________ Appendix 2 - PROJECT SUMMARY IN LAY TERMS Project Title: Asprosin-Ptprd receptor signaling: Effects on pancreatic β cell function and therapeutic strategies for diabetes treatment. Applicant: Ila Mishra Summary: The newly discovered hormone, asprosin, increases blood glucose levels, stimulates appetite, impairs insulin secretion and inhibits glucose uptake by the muscles, thereby exacerbating type 2 diabetes. This study aims to investigate the role of Ptprd receptor, and its small molecule inhibitor in asprosin mediated effects on beta cell function. Patients with diabetes typically exhibit elevated asprosin levels, while genetically reducing asprosin levels confers protection against diabetes. This same protection can be achieved by using a drug called an antibody that inhibits asprosin, presenting a promising therapeutic avenue. Our prior research demonstrated decreased appetite and blood glucose levels in diabetic mice following treatment with an asprosin-inhibiting antibody. However, the potential of this antibody to enhance pancreatic function and insulin sensitivity remains unexplored, a gap this grant proposal seeks to address. This investigation marks a crucial step forward in the development of novel drug for diabetes management.
StatusActive
Effective start/end date1/1/2512/31/25

Funding

  • Diabetes Research and Education Foundation: $50,000.00

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