BEET Root Juice to Reverse Functional Impairment in PAD: The BEET PAD Trial

BEET root juice to reverse functional impairment in PAD: The BEET PAD Trial University of Kentucky Scope of Work PI: Kate Kosmac PhD As a co-investigator in the BEET PAD TRIAL (Northwestern University, PI: Mary McGrae McDermott, MD), Dr. Kosmac and Peterson’s laboratory will measure changes in capillary density, satellite cell abundance, and central nuclei in calf muscle biopsy specimens obtained from participants randomized in Chicago who consent to muscle biopsy. Calf muscle biopsy specimens will be obtained in Chicago from participants randomized at Northwestern and at the University of Chicago and will be mailed to the University of Kentucky for analyses. Measures will be made in frozen human muscle biopsies shipped to the University of Kentucky by Northwestern University. The scope of work includes analysis of 129 muscle biopsy specimens mailed during years four and five (including baseline and follow-up calf muscle biopsy specimens). The scope of work includes analyzing approximately 72 in year four and 59 in year five. In addition, Drs. Kosmac and Peterson will participate in regular investigator Zoom meetings. Once data collection is completed, they will participate in data interpretation and manuscript writing.