Bone Adaptation During Orthodontic Tooth Movement in Rats

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Adults and orthodontic patients in general, desire shorter orthodontic treatment time. This trend has led to an increased focus on methods for accelerating orthodontic tooth movement. Many of the studies examining the mechanisms for expedited orthodontic tooth movement have been conducted in rodents. However, one of the surprising findings in rodents is a dramatic (~62-80%) reduction in bone volume in the inter-radicular bone concomitant with the tooth movement at 14-40 days. Interestingly, the bone volume is restored at later time points (~60 days). While there is no histological evidence to suggest that this loss of bone occurs in larger animal models, it still needs additional study. As a further complication, from human radiographic studies, it appears that molar protraction results in increased density of bone and dampens the rate of tooth movement. However, reduced bone volume in rodents will lead to an acceleration of tooth movement due to decreased resistance to movement and may lead to incorrect interpretation when results are generalized to humans. It has been proposed that the forces used to move teeth in rodents have been excessive and forces below 25cN should be used for molar protraction. Scaling animal size from humans to rodents would suggest that loads of
Effective start/end date7/1/166/30/17


  • American Association of Orthodontics Foundation: $5,000.00


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