Grants and Contracts Details
Description
Abstract
The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence
(CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and
cardiovascular systems. This vision will be accomplished through research performed by a
multidisciplinary group of outstanding investigators who are using cutting edge tools to
understand the pathobiology of vascular diseases. In this phase II application we seek to renew
funding for a second 5 years. We will continue the research partnership of three collaborating
institutions—Ocean State Research Institute (OSRI), the Rhode Island Hospital, and Brown
University. The applicant institution, OSRI, is the research and education nonprofit associated
with the Providence VA Medical Center, a teaching hospital affiliated with the Warren Alpert
Medical School of Brown University. In Phase I, the CPVB COBRE supported development of a
community of researchers, provided career development and research skill training, and
stimulated new research collaborations among the investigators, mentors, and other faculty.
Strong institutional support brought expert visitors to the center, resulting in additional research
collaborations. Teaching and mentoring activities of CPVB COBRE investigators enhanced
knowledge of vascular biology among undergraduate and graduate students, as well as
postdoctoral trainees and junior faculty. CPVB COBRE investigators have competed
successfully for $7.61 million in research funding during Phase I. Similar approaches will be
used during Phase II, and five outstanding junior investigators have been identified who bring
complementary backgrounds, skills, and research interests. New areas of research will be
pursued using innovative approaches that expand the scope of COBRE technical resources.
Thus, the CPVB COBRE will continue to broaden the scope and depth of vascular biology
research at the partnering Rhode Island institutions. The CardioPulmonary Vascular Biology
COBRE proposes the following specific aims for Phase II of funding: (1) Create a
multidisciplinary group of investigators in studies of vascular injury and repair. (2) Provide
research support, protected time, and mentoring to enable junior investigators to become
independent scientists and provide robust support for research career and professional
development. (3) Expand the CardioPulmonary Vascular Biology Center into new research
areas and thereby enhance and broaden vascular biology research at collaborating institutions.
(4) Provide services supporting vascular biology research and develop a self-sustaining
Cell/Organ Core. Accomplishment of these aims will result in a strengthened and broadened
CardioPulmonary Vascular Biology COBRE that will be the basis for new interdisciplinary
scientific collaborations, significant contributions to understanding of pulmonary and
cardiovascular diseases, and improvements in the health of the citizens of Rhode Island and the
nation.
Status | Finished |
---|---|
Effective start/end date | 9/3/23 → 5/31/24 |
Funding
- Ocean State Research Institute: $15,300.00
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