Career Development Award: Center for Appalachian Research in Environmental Sciences: Targeted Treatment of Arsenic-Induced Lung Cancer by PLK1 Inhibitors

In high-income countries, chronic diseases, which include heart disease, stroke, cancer, diabetes, respiratory conditions, and arthritis, have long been the leading causes of death and disability. Globally, more than 70 % of deaths are due to chronic diseases in the United States. Extensive review showed that toxic environmental agents are major contributors to the disproportionately high incidence of chronic diseases. Therefore, addressing the contributors of toxic environmental agents to chronic disease has broad implications for society, with large potential benefits from improved health. My career goals and objective is to identify novel and druggable signaling pathways that offer more effective treatment options for environmental exposure-related diseases and prevention.