Projects and Grants per year
Grants and Contracts Details
Description
The current renewal application forthe Center for Drug Abuse Research Translation (CDART) consists of a
core and four projects. The central integrated theme of the center is that reward seeking and inhibition are
biologically-based personality constructs associated with drug abuse vulnerability and that these constructs
are useful in the design of targeted drug abuse prevention messages. The Core will: (1) provide thematic
scientific integration of the different projects around the constructs of reward seeking and inhibition; (2)
create synergy across the four proposed projects and other ongoing projects on campus; (3) facilitate
interdisciplinary collaboration among basic and prevention sciences using both neurobehavioral and
psychosocial levels of analysis; and (4) oversee the long-range goal of translating our basic research into
practice. In Project I (Bardo, P1), a laboratory rat model will be used to determine if individual differences in
reward seeking and inhibition are associated with stimulant drug self-administration and mesocorticolimbic
cellular processes. In Project 2 (Kelly1 P1), human volunteers will be tested in a controlled laboratory
environment to assess if individual differences in reward seeking and inhibition are associated with
differences in drug reward and neural function as measured by functional magnetic resonance imaging
(fMRt) and electroencephalography (EEC). In Project 3 (Lynam, P1), a cohort of students transitioning from
high school to college will be used to determine if individual differences in reward seeking and inhibition are
associated with the initiation, escalation and/or cessation of drug use in a longitudinal design. In Project 4
(Zimmerman, P1), formative and experimental research will be conducted to determine if televised anti-drug
public service announcements (PSAs) are differentially effective among individuals who vary in reward
seeking and inhibition. Thus, all of the critical elements are now in place to assess at multiple levels of
discipline (biomedicine, psychology and health communication) the role of reward seeking and inhibition in
drug abuse vulnerability, with the long-term goat of improving the efficacy of anti-drug televised PSAs that
are tailored specifically for at-risk youth transitioriing to adulthood.
Status | Finished |
---|---|
Effective start/end date | 9/30/92 → 6/30/10 |
Funding
- National Institute on Drug Abuse: $2,088,446.00
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Projects
- 6 Finished
-
CDART - Center for Drug Abuse Research Translation - Minority Supplemnt
Bardo, M. (PI), Milich, R. (CoI) & Mullins, U. (CoI)
National Institute on Drug Abuse
9/30/92 → 6/30/10
Project: Research project
-
CDART-Center for Drug Abuse Research Translation (Project 1)
Bardo, M. (PI)
National Institute on Drug Abuse
9/30/92 → 6/30/10
Project: Research project
-
CDART-Center for Drug Abuse Research Translation (Project 4)
Cupp, P. (PI) & Donohew, R. (CoI)
9/30/92 → 6/30/10
Project: Research project