Projects and Grants per year
Grants and Contracts Details
Description
The link between chronic oral infections and general health has been recognized since the early 20th
century. During the last 2 decades, retrospective epidemiological studies and prospective longitudinal, as
well as intervention, studies have supported that these chronic oral infections with accompanying chronic
inflammation associate with various systemic diseases and their sequelae. This continuation application for
the Center for the Biobgic Basis of Oral/System Diseases (CBBO/SD) addresses major initiatives of the
National Institute of Dental and Craniofacial Research (NIDCR) regarding improving oral and general health
of the U.S. population. The CBBOISD is organized into 3 clnical projects: Project 1: Chronic Inflammation at
the Oral and CervicoNaginal Mucosa; Project 2: Physiology of the Stress Response in Patients with
Temporomandibular Disorders and Fibromyalgia; Project 3: Coordinated Oral-Intestinal Immune Response
in Patients with Inflammatory Bowel Diseases; and 2 translational science projects: Project 4: Ontogeny of
Innate Immune Responses at Mucosal Surfaces; and Project 5: Gene Therapy for Orofacial Pain. These
projects enlist junior investigators from the Colleges of Dentistry, Nursing, and Medicine, as well as senior
mentors/co-investigators from multiple colleges at UK. The thematic interface of the projects focuses on the
`contribution of chronic inflammation to oral and systemic diseases. They engage populations of expectant
women, patients with chronic orofacial pain, and inflammatory bowel disease. These clinical projects interact
with the translational projects at the level of a common understanding of innate immune responses and
inflammation, and novel therapeutic intervention strategies for the chronic orofacial pain. The CBBO/SD
provides an infrastructure for development of the junior faculty by providing grants management support,
educational opportunities, a biostatistics/bloinformatics core, and a clinical research center. The continuation
of the CBBO/SD is supported by the success during the initial tenure of the center in transitioning junior
investigators towards independent funding, coupled with substantial investment from the university and
individual colleges.
Status | Finished |
---|---|
Effective start/end date | 9/23/04 → 7/30/10 |
Funding
- National Center for Research Resources
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Projects
- 1 Finished
-
COBRE Center for the Biologic Basis of Oral/Systemic Disease (CBBOSD)
Ebersole, J., Arsenescu, R., Ashford, K., Bathke, A., Branscum, A., Bush, H., Carlson, C., Crofford, L., DANAHER, R., Danaher, R., Dawson, D., De Leeuw, R., High, K., Kaetzel, C., Kryscio, R., Miller, C., Novak, K., Novak, M., Skelton, J., Stromberg, A. & Yepes, J.
National Center for Research Resources
9/23/04 → 7/30/10
Project: Research project