Projects and Grants per year
Grants and Contracts Details
Description
The objectives of the Center for the Biologic Basis of Oral/Systemic Diseases CCBBOSD) are: RESEARCH: To develop a
better understanding of the biologic principles that underpin the observed linkages of chronic oral infections and
inflammation with systemic disease sequelae; and TRAINING: To use this research focus as a platform to develop
promising young investigators in oral health sciences and enhance their competitiveness for external funding, including
NIH grant support. We will accomplish these objectives by: Organizing a cadre of established, funded scientists to
examine crucial questions related to oral and systemic health linkages, Providing young research faculty with
opportunities for interdisciplinary training in oral health sciences and systemic disease, Mentoring young faculty in
research projects focused on oral infections, host responses, and systemic disease that will lead to success as independent
mH-funded researchers. Developing and supporting core facilities and resources to optimize the research enterprise of
the CBBOSD faculty, Facilitating pilot projects. as well as intra- and inter-university collaborations among CBBOSD
faculty. and other researchers at the University of Kentucky. Strategic hiring of new faculty to complement existing
strengths to contribute to a critical mass of funded investigators in the biology of oral-systemic diseases. To address this
need, we have organized the research activities and leadership of the CBBOSD into 2 broad thematic areas. These
thematic areas will incorporate 6 research projects that are integrated with respect to underlying concepts, methodologies,
and availability of biological specimens. THEMATIC AREA 1: Oral infections: Translational studies of hostparasite
interactions; Proiect 1: Oral Infections and HIV Recrudescence: Proiect 2: Oral Infections: Inflammation.
Lipid Metabolism. and Atherosclerosis: Proiect~: Oral Infections: Genomic Analvsis of Host Responses to Polvrnicrobial
Infections:. THEMATIC AREA 2: Oral infections: Clinical implications for systemic disease; Proiect 4: Oral
Infections: Impact on Gestational Diabetes: Project~: Oral Infections: Dietarv Re~ulation of Local and Svstemic
Inflammatorv Responses: Proiect 6: Oral Infections: Viral/Bacterial Interactions in Chronic Diseases. These research
projects are integral to the goals of the CBBOSD because they focus on critical questions of the biology of chronic oral
infections and contribution to alterations in systemic health. The overall focus of the CBBOSD is diverse to enable this
interdisciplinary research team to: (i) address the myriad of challenges in understanding critical parameters of the
interplay between infections and disease in the oral cavity, and (ij) use the available expertise of senior faculty at UK with
experience in mentoring young investigators. Thus, junior investigators will be integrated into research projects with
established, funded faculty who use state-of-the-art cellular and molecular approaches to explore the biologic basis of this
relationship. The breadth of science and varied senior research expertise assures that the CBBOSD will provide
opportunities for many junior investigators. who will have the capability to interact within this nurturing environment.
The outcomes of this mentored. nurturing structure will enhance the maturation of oral health research at UK, through
the College of Dentistry, and synergize in expanding NIH-funded research in the Commonwealth of Kentucky.
Status | Finished |
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Effective start/end date | 7/1/05 → 7/31/07 |
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Projects
- 1 Finished
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Center for the Biologic Basis of Oral/Systemic Diseases: AEC
Ebersole, J., Al-Sabbagh, M., Bathke, A., Boissonneault, G., Bondada, S., Branscum, A., Cidambi, S., Daugherty, A., Dawson, D., Ferguson, J., Huang, C., Kesavalu, L., King, V., Kryscio, R., Li, M., Loftin, C., Miller, C., Novak, K., Novak, M., Skelton, J., Smiley, J., Stromberg, A., Tai, H., Thomas, M. & Wedlund, P.
National Center for Research Resources
9/23/04 → 7/31/07
Project: Research project