Projects and Grants per year
Grants and Contracts Details
Description
ABSTRACT
Our T32 training program entitled “Training in Translational Research in Alzheimer’s Disease and Related
Dementias (TRIAD)” aims to provide cross-disciplinary training from bench to bedside, to produce a new
translational workforce that is critically needed to advance effective treatments for Alzheimer’s disease and
related dementias (ADRD). Predoctoral and postdoctoral trainees will receive rigorous training through a
transdisciplinary and integrative mentoring program that spans the discovery continuum from molecular/
biochemical methods, preclinical translational approaches, and clinical research. The thematic focus is on
major ADRD risk factors, including cerebrovascular dysfunction, neuroinflammation, brain injury, and
genetic/lifestyle risks. The 23 faculty mentors include well-funded investigators with established and extensive
collaborative relationships and successful track records in training. The faculty mentors encompass diverse yet
complementary areas of expertise along the translational continuum from cell and molecular biology, genetics,
and data science, through preclinical model systems, therapeutic development, neuroimaging, neuropathology,
clinical trials, and longitudinal clinical studies. The majority (20) of these mentors are faculty in the University of
Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer’s Disease
Research Center (ADRC). The two-year training plan will emphasize 1) experiential research and learning of
core competencies required to become independent leaders in clinical/ translational research, 2) a tailored
educational plan that emphasizes the translational continuum from basic science to clinical to community, and
3) multidisciplinary mentoring from highly committed program faculty. Each trainee will develop an
individualized development plan to enable advancement to independent research and funding. Trainees will
participate in a structured educational program that includes a dedicated AD101 course, training in the
responsible conduct of research, Good Research Practice training, and workshops and seminars, including
relevant clinical grand rounds. Trainees will gain career development experiences through the monthly trainee-
organized team meeting, presentations at the annual Markesbery Symposium on Aging and Dementia, and
grant writing workshops. Trainees will also have the opportunity to participate in an experiential learning
externship, which can include an off-site training course, visiting a collaborator’s lab outside Kentucky to
develop additional research skills, or visiting another ADRC to observe/shadow/learn specific aspects based
on the trainee’s research interests. Quantitative and qualitative metrics for evaluation of trainees, mentors, and
the training program will assure a high-quality and effective training experience. Overall, this T32 program is
uniquely positioned to fill a growing need for a diverse, translational research workforce with the cross-
disciplinary team science skills required to conduct rigorous and cutting-edge basic, translational, and clinical
research to develop and advance effective interventions for Alzheimer’s disease and related dementias.
Status | Finished |
---|---|
Effective start/end date | 8/1/22 → 7/31/23 |
Funding
- National Institute on Aging
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 1 Finished
-
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)
Van Eldik, L. (PI), Cassis, L. (CoI), Gerhardt, G. (CoI), Saatman, K. (CoI), Schoenberg, N. (CoI), Spear, B. (CoI), Murphy, M. (CoPI) & Webb, N. (Former CoI)
8/1/22 → 7/31/23
Project: Research project