CHOP Millennium Pharm AAML 1031

  • Greenwood Cassidy, Martha (PI)

Grants and Contracts Details


Confidential Sponsor: National Cancer Institute through Children's Hospital of Philadelphia (CHOP) with support from Millennium Pharmaceuticals, Inc. Phase 3 Title: Bortezomib and Sorafenib Tosylate in Patients With Newly Diagnosed Acute Myeloid Leukemia With or Without Mutations Purpose This randomized phase II/III trial is studying how well giving bortezomib and sorafenib tosylate together works in treating patients with newly diagnosed acute myeloid leukemia with or without mutations. Bortezomib and sorafenib tosylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Giving bortezomib and sorafenib tosylate together with combination chemotherapy may be an effective treatment for acute myeloid leukemia
Effective start/end date2/14/1311/30/13


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