Projects and Grants per year
Grants and Contracts Details
Description
2.1 Study Objectives
The objective of this within-subject study is to assess the effect of oral cannabidiol (CBD; 0, 200,
400, 800 mg) on smoked marijuana’s (0, 5.6% THC) subjective, reinforcing, cognitive, and
cardiovascular effects. This experiment is expected to reveal CBD’s intrinsic effects when
combined with placebo marijuana, as well as its ability to modulate the behavioral effects of
active marijuana.
2.2 Study Design
At each site, 12 non-treatment-seeking marijuana smokers will complete 8 outpatient clinic test
sessions over the course of 8 weeks. Three sites will participate (and will complete a total of 36
participants across sites).
2.3 Treatment
Participants will be administered oral cannabidiol (0, 200, 400, 800 mg) 90 min prior to smoking
50% of a marijuana cigarette (0, 5.6% THC). The order of administration of CBD and marijuana
dose conditions will be counter-balanced. At select time points, participants will complete mood
scales and performance tasks, and their heart rate and blood pressure will be measured.
Participants will also have the opportunity to self-administer up to 3 additional puffs of marijuana
to assess cannabidiol’s influence on marijuana reinforcement.
2.4 Safety Assessments
Vital signs (heart rate and blood pressure) will be monitored during each session.
2.5 Efficacy Assessments
Efficacy will be assessed by measuring the effect of oral cannabidiol (0, 200, 400, 800 mg) on
smoked marijuana’s (0, 5.6% THC) reinforcing, subjective, cognitive, and physiological effects.
2.6 Analyses
A between and within-subject repeated measures analysis of variance (ANOVA) with planned
comparisons will be implemented to determine the effects of cannabidiol on marijuana’s
reinforcing, subjective, cognitive, and physiological effects for each marijuana strength (active
vs inactive).
Status | Finished |
---|---|
Effective start/end date | 9/15/10 → 8/31/15 |
Funding
- University of Cincinnati
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Projects
- 1 Finished
-
Clinical Trial Network, Ohio Valley Node
Walsh, S. (PI), Babalonis, S. (CoI) & Lofwall, M. (CoI)
9/15/10 → 8/31/15
Project: Research project