Projects and Grants per year
Grants and Contracts Details
Description
The overall objectives of the COBRE in the Molecular Basis of Human Disease at the University of
Kentucky continue to be: (I) enhancing multidisciplinary research on the study of human disease, (ii)
enhancing research competitiveness of the junior faculty who serve as principal investigators on research
projects and pilot projects, and (iiG building and strengthening new core facilities to enhance the research
capabilities of the principal investigators. their co-investigators, and researchers throughout the University.
Significant progress has been made to achieve these objectives. This past year three of the current
COBRE Pis submitted new research grants. with two new grants received. Only the two new COBRE Pis
(201012011) did not submit grants. COBRE faculty published or have in press over 33 papers this past
year and made 16 presentations at conferences and meetings. .
The core facilities supported by this COBRE grant continue to be broadly used by the COBRE faculty.
The external advisory board met at the University in October of 201 0 and heard presentations from each of
the principal investigators and core directors. Fallowing these meetings the external advisory board met
with the PI Dr. Hersh and reviewed the progress of the projects and cores. This information was
subsequently passed on to the junior faculty Pis, pilot grant Pis, and core directors. All projects were
deemed to be progressing, however It was recommended to decrease the funding of one project. In
addition, two new faculty Pis, Dr. Emilia Galperin and Dr. Yvonne Fondufe-Mittendorf, were recruited to UK
and. based on the recommendation of the extemal advisory board, made Pis on COBRE projects. Dr.
Galperin's project is entitled ·Understanding the role of Shoc2 protein in spatio-temporal regulation of
extracellular signal-related kinase (ERK) kinase cascade: and Dr. Fondufe-MiUendorfs project is entitled
"A study into understanding the molecular basis of epigenetic transcriptional silencing."
The COBRE mentors and Pis continued to meet on a biweekly basis throughout the year. During this time
the COBRE principal investigators and pilot project investigators made informal presentations, and
discussed their projects, grant writing, publications, etc. These mentoring sessions prove to be very
effective and useful for facilitaUng the research projects and for stimulating the junior faculty. The COBRE
mentors began meeting on a monthly basis as an advisory group to review progress of the Pis and to
evaluate cores. We contlnued our training program on ethical and responsible conduct in research. All of
the trainees involved in the grant participated and will continue to participate in this training program.
This year one new pilot award was made to facilitate program project applications. The title of the project
funded is "The roles of integrin-daudin protein complexes in metastatic and chemoresistant human breast
cancer". In addition through a supplemental NCRR ARRA grant a new core for the production of viruses for
research was contInued.
In addition to our regular research project, we have one Plannint Grant committee, supported by funds
awarded in the Administrative Core, with faculty who are working to generate preliminary data for a multi-PI
or program project grant application.
Planning grant to determine the role of the RNA processing protein FUSrrLS in ALS (Zhu)
This planning grant group consists of Drs. Halning Zhu, Jianhang Jia. and Stefan Stamm. The central
hypotheSis of the application is that the ALS-related mutations in FUS impair the protein's RNA processing
function and ultimately cause motor neuron degeneration. This application is to use a combination of
techniques including biochemistry, cell biology. RNA biology and Drosophila genetics, to determine what
RNA processing capabilities of FUS are impaired by the ALS-related mutations, and how such dysfunction
can cause motor neuron death.
Status | Finished |
---|---|
Effective start/end date | 9/1/04 → 6/30/12 |
Funding
- National Center for Research Resources: $2,149,010.00
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Projects
- 9 Finished
-
Center of Biomedical Research Excellence in the Molecular Basis of Human Disease--Project 5
Wang, Q. (PI)
National Center for Research Resources
7/1/11 → 6/30/12
Project: Research project
-
Center of Biomedical Research Excellence in the Molecular Basis of Human Disease--Organic Synthesis Core
Watt, D. (PI)
7/1/11 → 6/30/12
Project: Research project
-
Center of Biomedical Research Excellence in the Molecular Basis of Human Disease--Imaging Core
Moncman, C. (PI) & Dutch, R. (Former PI)
National Center for Research Resources
7/1/11 → 6/30/12
Project: Research project