Completion of the Marty Driesler Lung Cancer Study: Early Detection of Lung Cancer in a High Risk Population

Southeastern Kentucky has one of the highest incidence of lung cancer in the United States, but researchers do not know why it is so common in this area. Risk factors for lung cancer include tobacco exposure, age, and the development of chronic obstructive lung disease. Since 2004, the Marty Driesler Cancer Project has been studying the use of computed tomography (CT) scans to screen for lung cancer in Kentucky's 5~ congressional district. By picking up lung cancers in an earlier stage, we hope to improve the survival from this dreaded disease. The current proposal extends the Marty Driesler lung cancer screening project and provides funds to complete the study of individuals at highest risk of lung cancer-namely, those from Appalachian Kentucky who have certain risk factors for lung cancer: a) age (55 to 75 years), b) poor pulmonary function (by breathing tests) and c) a history of active or past tobacco abuse. This study is trying to show that lung cancer screening using low-dose CT scans in rural community hospitals, in a group of people at high risk for lung cancer is valid, feasible and effective for the early detection of lung cancer. We will also catalogue the types of abnormalities found using CT scans in this group of people and collect biological specimens from them that will help in developing blood tests to detect lung cancer at even earlier stages in the Mure. The Marty Driesler Cancer Project is already an ongoing, community-based research initiative and this funding will allow the continuation of the project within the high-risk area of Appalachian Kentucky. This proposal continues the important work begun by the Marty Driesler Project and ensures the success of CT screening in rural Kentucky. It also allows people living in rural communities to participate in research that will directly improve their health.