Grants and Contracts Details
Description
Abstract
Early reports suggest that many patients have persistent symptoms lasting months after infection with
SARS-CoV2. One US study of 274 symptomatic outpatients with COVID-19 reported that 35% had not
returned to their normal state of health 2-3 weeks after initial testing; cough, fatigue, and shortness of
breath were the most commonly reported enduring symptoms. (1) An Italian report of 143 patients
hospitalized with COVID-19 described that only 13% of patients were symptom-free 60 days after initial
symptom onset; in that study, fatigue, dyspnea, joint pain, chest pain, and cough were the most
common enduring symptoms. Nearly half reported persistent impairment of health-related quality of
life. (2) There is considerable discussion of this phenomenon—coined “long COVID” or “COVID long
haulers” in the lay press and, increasingly, in the medical literature. (3) With over 8 million Americans
having tested positive for SARS CoV2 by October 2020 and infections on the rise, the public health
impact of delayed recovery is enormous. However, the etiologies of these persistent symptoms and
impairments remain unclear.
The current proposal, FIRE CORAL, will identify 80 patients enrolled in the post-hospital assessment
component of the BLUE CORAL study who are able to participate in in-person assessments at
participating PETAL Network sites. All FIRE CORAL patients will be scheduled for up to3 return visits
during the 12 month after hospital discharge time period for a battery of systematic assessments
(detailed in Table A) including pulmonary function (spirometry, lung volume, and diffusing capacity),
chest imaging (non-contrast computed tomography – participant’s first visit only), function (6-minute
walk testing and short performance physical battery), respiratory questionnaires and biospecimen
collection. If participants complete their first study visit prior to 6 months after hospital discharge, they
(up to 60 total) will be given the opportunity to return for an additional visit 6-9 months after hospital
discharge, scheduled at least 2 months after the prior visit. Up to 80 participants who complete at least
one visit within the 3-9 month after hospital discharge time point will complete a 12-month visit.
Status | Finished |
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Effective start/end date | 3/1/21 → 10/31/23 |
Funding
- Wake Forest University: $33,618.00
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