Projects and Grants per year
Grants and Contracts Details
Description
Cytokines can not only serve directly as a therapeutic drug but also help to identify drug targets and
disease biomarkers. For example, Drugbank lists 54 approved cytokine-based drugs. The cytokine
profiling is an important tool for measurement of cytokine release, diagnosis classification of disease
stage, and surveillance for therapy. Data analysis is absolutely critical for revealing and extracting the
information concealed in cytokine profiling studies. Although software exists for analyzing metabolomics
data, such as the R package "mixOmics" and software specifically for analyzing cytokine concentration
data such as "CytokineExplore", this software can be adapted to conduct only a part of cytokine analysis
in the context of diabetes; as such, these packages are insufficient to reveal information and display
results concealed in the cytokine profiling data.
The analytic tool under our development will provide a general utility for analyzing cytokine profiling
data to reveal important information for the identification of potential drug targets and disease
biomarkers for diabetes. Detailed cytokine profiling will also benefit people with prediabetes and
diabetes because it may differentiate prediabetes from diabetes so that it may help to prevent
prediabetes from progressing to diabetes. Cytokine profiling may help the use of targeting T cells as an
effective approach for prevention/management of metaflammation in diabetes patients. This pilot grant
should provide us an excellent opportunity for promoting the collaboration to generate fruitful research
outcome and external grant application on diabetes for years to come.
Status | Finished |
---|---|
Effective start/end date | 4/5/23 → 9/30/24 |
Funding
- Washington University in St. Louis
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Projects
- 1 Active
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University of Kentucky Pilot and Feasibility Research Program
Kern, P. (PI), Mishra, I. (CoI), Nikolajczyk, B. (CoI), Wang, S. (Former CoI) & Zhang, X. (Former CoI)
Washington University in St. Louis
4/5/23 → 3/31/25
Project: Research project