Developing an Analytic Tool on Cytokine Profiling for Diabetes

Grants and Contracts Details

Description

Cytokines can not only serve directly as a therapeutic drug but also help to identify drug targets and disease biomarkers. For example, Drugbank lists 54 approved cytokine-based drugs. The cytokine profiling is an important tool for measurement of cytokine release, diagnosis classification of disease stage, and surveillance for therapy. Data analysis is absolutely critical for revealing and extracting the information concealed in cytokine profiling studies. Although software exists for analyzing metabolomics data, such as the R package "mixOmics" and software specifically for analyzing cytokine concentration data such as "CytokineExplore", this software can be adapted to conduct only a part of cytokine analysis in the context of diabetes; as such, these packages are insufficient to reveal information and display results concealed in the cytokine profiling data. The analytic tool under our development will provide a general utility for analyzing cytokine profiling data to reveal important information for the identification of potential drug targets and disease biomarkers for diabetes. Detailed cytokine profiling will also benefit people with prediabetes and diabetes because it may differentiate prediabetes from diabetes so that it may help to prevent prediabetes from progressing to diabetes. Cytokine profiling may help the use of targeting T cells as an effective approach for prevention/management of metaflammation in diabetes patients. This pilot grant should provide us an excellent opportunity for promoting the collaboration to generate fruitful research outcome and external grant application on diabetes for years to come.
StatusFinished
Effective start/end date4/5/239/30/24

Funding

  • Washington University in St. Louis

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