Projects and Grants per year
Grants and Contracts Details
Description
There is a great unmet need to distinguish clinically between the different causes of
cognitive impairment in elderly individuals for the sake of early diagnosis and
therapeutic intervention designed to improve outcomes for patients. The University of
Kentucky Alzheimer’s Disease Center (UK-ADC) has been at the forefront of studying
the most prevalent causes of Non-AD MCI, demonstrating that over two-thirds of elderly
patients have non-AD brain conditions that deleteriously affect cognition. We have
chosen to focus on MCI due to cerebrovascular disease (MCI-CVD). This application
focuses on defining the pathological underpinnings and relationships of specific risk
factors to MCI-CVD, developing clinical diagnostic criteria for MCI-CVD using imaging,
serum, and CSF biomarkers that will also allow longitudinal evaluation and assessment
of therapeutic interventions in MCI-CVD. As such, the current application represents a
comprehensive bench-to-bedside translational program designed to directly increase
our understanding of and impact the major cause of cognitive decline in the elderly
population today. The multidisciplinary team represents leaders in the field with proven
track histories of scientific accomplishments and collaborative enterprise in the area of
MCI. Successful completion of project aims will allow an integrated understanding of
MCI-CVD with the potential for tremendous impact on one of the major healthcare
crises facing the nation today.
Status | Finished |
---|---|
Effective start/end date | 9/26/12 → 6/30/16 |
Funding
- National Institute of Nursing Research: $1,588,654.00
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Projects
- 2 Finished
-
Early detection and prevention of mild cognitive impairment due to cerebrovascular disease
Jicha, G. (PI), Abner, E. (CoI), Andersen, A. (CoI), Biddle, M. (CoI), Dobbs, M. (CoI), Han, D. (CoI), Kryscio, R. (CoI), Moser, D. (CoI), Nelson, P. (CoI), Neltner, J. (CoI), Schmitt, F. (CoI) & Smith, C. (CoI)
National Institute of Nursing Research
9/26/12 → 6/30/16
Project: Research project
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Supplement - Early detection and prevention of mild cognitive impairment due to cerebrovascular disease
Moser, D. (PI), Bruckner, G. (CoI), Estus, G. (CoI), Jicha, G. (CoI), Lennie, T. (CoI) & Mudd, G. (CoI)
National Institute of Nursing Research
9/23/12 → 6/30/16
Project: Research project