Effects of Pollution Resistance on Polychlorinated Biphenyl Mediated Endocrine Disruption

The goal ofthis study is to determine whether acquired resistance to polychlorinated biphenyls (PCBs), as measured by altered expression chytochrome P450 IA (CYPIA), results in resistance to the endocrine disrupting effects of these compounds. We hypothesize that acquired resistance confers additional resistance to the hormone disrupting actions of these compounds. Acquired resistance to PCBs has been reported in a number of fish populations but the consequences of this resistance on endocrine function are unknown.