Fellowship for Thomas York: :Is Rrad Deletion Superior to Phosphodiesterase Inhibition for Heart Function?

Myocardial contraction is regulated by sympathetic nervous system input via catecholamines activating beta- adrenergic receptors (beta-AR). By using a series of pharmacological approaches, I will dissect the relative contribution of a class of enzymes known as phosphodiesterases in WT and cRadKO cardiomyocytes. Recent studies showed that subclass 1 of phosphodiesterases works via targeting the same Ca2+-channel complex as influenced by Rrad. In this 10-week study I will determined the relative strength of effects of phosphodiesterase 1 inhibition compared to reduced Rrad. I will also participate in weekly lab meetings and have opportunities to present results of my work as part of the UK summer undergraduate cardiovascular research program.