## Grants and Contracts Details

### Description

This project will enable systematic design of efficient molecular circuits for fast computation of complex
mathematical functions. The design of molecular computing circuits will be systematic because the project
will develop a new level of design abstraction that accepts mathematical representation of desired
computations. It will create an end-to-end compiler that transfers the mathematical representation to CRNs,
and then generates candidate DNA reactions and sequences. The developed circuits will be fast because
they work based on fractional coding. Unlike traditional encodings that need to wait for the equilibrium
concentrations of molecules, for fractional coding, inputs/outputs are ratios of pairs of molecular
concentrations. The ratios reach their final values much faster than molecular concentrations. This project
will expand the computational power of molecular computing circuits to complex computations through two
approaches: 1) it will map all stochastic computing logic circuits to molecular circuits, 2) it will implement
finite state Markov chains by molecular reactions. Finally, the project will develop new approaches for
performing ANNs and signal processing algorithms with molecular reactions.
This project will have a significant impact on the field of bio-design automation because it will introduce
and attempt to realize the idea of automated design of molecular circuits, starting from high level
mathematical or algorithmic representation. If successful, the project will deliver a complete framework and
associated software tool that enables a person who is not a skilled biologist to design and study complex
biological systems. In the realm of biomolecular computation, there is established prior work in molecular
circuits for computing different sorts of mathematical functions such as polynomials [41],[42], and logarithms
[43],[44]. As of now, however, no systematic method has been proposed for computing complex general
mathematical functions within a molecular circuit.

Status | Active |
---|---|

Effective start/end date | 10/1/21 → 9/30/24 |

### Funding

- National Science Foundation: $399,396.00

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