Function and Stability of Expanded Regulatory T cells in Obese Renal Transplant Candidates

Grants and Contracts Details


About 75% of the adult population in the US is considered overweight or obese and current estimates indicate that these rates are likely to remain steady or rise1-4. The Transplant Center at the University of Kentucky serves a significant portion of the Appalachia region (West Virginia, eastern Kentucky, northern Tennessee and southern Ohio), one of the most obese regions in the nation with high obesity rates reported in more than 80 percent of the counties5. In 2016, our center evaluated nearly 1,000 patients with end-stage renal disease (ESRD), of which 54.2% had a body mass index (BMI) equal or greater than 30 Kg/m2 (obese status). A recent national survey of clinical outcomes in kidney transplant recipients revealed a BMI over 50 Kg/m2 leads to higher incidence of perioperative death (more than 5 fold), delayed graft function (2 fold) and death (82% higher) compared to patients with BMI
Effective start/end date5/18/1812/31/20


  • National Institute of Allergy and Infectious Diseases: $153,000.00


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.