Grants and Contracts Details
Description
ABSTRACT This project interrogates the regulation and functions of scar-forming astrogliosis
at the chronic lesion versus diffuse astrogliosis in the degenerating axonal tracts following SCI.
We will distinguish these two types of astrogliosis based on their spatial separation in the injured
spinal cord, our use of distinct SCI models, and different outcome measures. We will genetically
manipulate the level of astrogliosis in LZK mutant mice, and assess LZK-CSF1 as a common
mechanism underlying the distinct functions of scar-forming versus diffuse astrogliosis.
Specifically, Aim 1 determines the role of scar-forming astrocytes in pathological retention of
macrophages at the chronic SCI scar. Aim 2 examines the role of diffuse astrogliosis in promoting
axon sprouting distal to the lesion. Aim 3 assesses the therapeutic potential of AAV-mediated
local targeting of either scar-forming or diffuse astrogliosis to promote neural repair after SCI.
Status | Active |
---|---|
Effective start/end date | 4/1/21 → 3/31/26 |
Funding
- National Institute of Neurological Disorders & Stroke: $1,518,525.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.