FY22 Colon Cancer MSI MMR Study

Exploring Factors that Contribute to the Persistently High Colon Cancer Incidence and Mortality Rates in Kentucky FY22 Colon Cancer MSI MMR Study Pediatric brain and central nervous system tumors are the most common solid tumors and are the leading cause of disease-related death in children in the US. PBCNST incidence rates in KY are significantly higher in the US as a whole and are even higher among Kentucky''s Appalachian children. To understand and eventually eliminate such cancer disparities among KY children, the Contractor will perform continued population-based data collection to facilitate research that is needed to gain a thorough understanding of the epidemiology and etiology of the disease. Contractor will expand upon the successful 2018-2020 KY Pediatric Cancer Research Trust Funds population-based study to identify factors associated with the high incidence of PBCNST in KY. Contractor will leverage the infrastructure provided by the KY Cancer Registry, its Virtual Tissue Repository and the NIH Kids First Data Resource Center to expand upon for genetic sequencing and information directly from the PBCNST survivors and their families. This work will generate a comprehensive dataset to empower investigations into the factors behind this burden in KY.