Grants and Contracts Details
Description
The goal of this proposal is to develop methods to improve the analysis of pharmaceuticals
using solid-state NMR spectroscopy (SSNMR). The proposal is divided into two parts. The first
part is the construction of magic-angle spinning (MAS) NMR probes to improve the throughput
of solid-state NMR spectrometers. In the previous proposal, a multiple-sample NMR probe was
shown in which the spinning systems could be rapidly shuttled in and out of the homogeneous
region of the static magnetic field. While the spectrum of one sample is being acquired, the
magnetization of the other samples will be returning to equilibrium in the inhomogeneous region
of the field. In this proposal, two new probe designs are proposed. The first design utilizes two
magic-angle spinning systems that are simultaneously in the homogeneous region of the
magnet. This allows doubling of the throughput of a conventional NMR spectrometer without
requiring the more advanced hardware necessary for moving the probe in the magnet. It also
can be used with very fast relaxing samples, as the switching time between modules can be
almost instantaneous. The second design addresses one of the challenges of the current
multiple-probe technology, namely the ability to move a large NMR probe within the bore of a
magnet. The concept involves rotating a MAS system that contains 3-6 individual rotors that can
be rotated about an axis into the homogenous region of the magnet, similar to how a revolver
functions. The advantage of this design is that the entire probe no longer moves in the bore of
the magnet, but only the spinning system rotates. This allows for potentially much faster
switching speeds.
Status | Finished |
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Effective start/end date | 11/14/12 → 12/31/13 |
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