GOALI New Techniques for Solid-State NMR Studies of Pharmaceuticals

  • Munson, Eric (PI)

Grants and Contracts Details


The goal of this proposal is to develop methods to improve the analysis of pharmaceuticals using solid-state NMR spectroscopy (SSNMR). The proposal is divided into two parts. The first part is the construction of magic-angle spinning (MAS) NMR probes to improve the throughput of solid-state NMR spectrometers. In the previous proposal, a multiple-sample NMR probe was shown in which the spinning systems could be rapidly shuttled in and out of the homogeneous region of the static magnetic field. While the spectrum of one sample is being acquired, the magnetization of the other samples will be returning to equilibrium in the inhomogeneous region of the field. In this proposal, two new probe designs are proposed. The first design utilizes two magic-angle spinning systems that are simultaneously in the homogeneous region of the magnet. This allows doubling of the throughput of a conventional NMR spectrometer without requiring the more advanced hardware necessary for moving the probe in the magnet. It also can be used with very fast relaxing samples, as the switching time between modules can be almost instantaneous. The second design addresses one of the challenges of the current multiple-probe technology, namely the ability to move a large NMR probe within the bore of a magnet. The concept involves rotating a MAS system that contains 3-6 individual rotors that can be rotated about an axis into the homogenous region of the magnet, similar to how a revolver functions. The advantage of this design is that the entire probe no longer moves in the bore of the magnet, but only the spinning system rotates. This allows for potentially much faster switching speeds.
Effective start/end date11/14/1212/31/13


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