Hip Joint Bone and Cartilage Bone and Cartilage Health and Mechanics in Patients with Femoroacetabular Impingement Syndrome

Grants and Contracts Details


Femoroacetabular impingement syndrome (FAIS) is an orthopaedic condition consisting of abnormal hip joint morphology, which may lead to abnormal hip joint mechanics and is also associated with severe hip joint pain and dysfunction. Many FAIS patients that fail conservative treatments undergo hip arthroscopy in order to restore normal hip joint morphology and reduce clinical symptoms yet the longitudinal effects of hip arthroscopy on hip joint bone and cartilage health and function are not well understood and require further study. Quantitative assessment of hip joint bone remodeling, cartilage health and corresponding hip joint bone and cartilage mechanics in patients with FAIS both before and after hip arthroscopy will provide a comprehensive understanding of long-term hip joint health and function. The principal investigator (PI) of this KL2 award seeks to employ a novel approach consisting of positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), finite element analysis (FEA) and biochemical biomarker analysis in understanding the effects of FAIS and surgical intervention on hip joint health and mechanics with a long-term goal of using the results of this study to improve upon current FAIS-related interventions and surgical techniques. The PI proposes a long-term study where FAIS patients and healthy asymptomatic controls will undergo PET-imaging, MRI, biochemical biomarker analysis and biomechanical assessment at baseline/presurgery and 12-months follow-up time points. The proposed study will allow the applicant to build upon his current expertise in lower extremity biomechanics and applications of quantitative MRI and to acquire the knowledge and expertise needed in using PET-imaging and biochemical biomarker analyses in establishing a more comprehensive assessment of the effects of FAIS and hip arthroscopy on hip joint bone and cartilage health and function. The PI has put together a strong training plan and diverse advisory committee consisting of a physical therapist, radiologist, orthopaedic surgeon, multiple biomechanists, MR-physicists and Biomedical Engineers with varying expertise in PET-imaging, MR-based measurements of cartilage health, FEA and biochemical biomarkers associated with osteoarthritis. The proposed training plan and mentorship will aid the PI in his career development and aid in accomplishing the goals of this KL2 award. In addition to the proposed training plan and mentorship, the PI has strong institutional support which will provide the necessary University-based resources for the PI in accomplishing the goals of this KL2 award and establishing himself as an independent investigator not only at the University of Kentucky but also within the fields of MSK imaging and mechanics. The techniques and knowledge obtained during this KL2 award will allow the PI to develop a unique multidisciplinary platform, which will lead to the establishment of his own independent line of research and in turn accelerate the PI’s transition to an independent investigator.
Effective start/end date8/15/165/31/21


  • National Center for Advancing Translational Sciences


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