In Vivo patterns of Receptor Activation by Odorants

Grants and Contracts Details


The parent grant award for this administrative supplement request investigates the patterns of odorant receptor responses evoked by odors and the cell and molecular biology of the olfactory sensory neurons that express these odorant receptors. Deficits in olfactory performance are an early symptom for many patients suffering from Alzheimer’s Disease (AD) and AD patients typically show neuropathology in brain regions that process olfactory information, including the loss of olfactory sensory neurons. The susceptibility of these neurons to AD-related neurodegeneration and our highly detailed knowledge of the biology of these neurons, such as knowing the identity of all genes they express, are fundamental reasons they are advantageous models for investigating the onset of AD. Investigating the onset of AD is critical given that therapies targeting late stages of the disease have been unsuccessful. In this administrative supplement request we propose to take advantage of the accessibility of olfactory sensory neurons and our ongoing study of their primary function to carefully and deeply investigate phenotypic changes in olfactory sensory neurons from two types of mouse models of AD, one a model of early onset AD and the other a model of disease susceptibility and late onset AD.
Effective start/end date12/1/1511/30/22


  • National Institute on Deafness & Other Communications


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