Projects and Grants per year
Grants and Contracts Details
Description
The parent grant award for this administrative supplement request investigates the patterns of odorant receptor
responses evoked by odors and the cell and molecular biology of the olfactory sensory neurons that express
these odorant receptors. Deficits in olfactory performance are an early symptom for many patients suffering
from Alzheimer’s Disease (AD) and AD patients typically show neuropathology in brain regions that process
olfactory information, including the loss of olfactory sensory neurons. The susceptibility of these neurons to
AD-related neurodegeneration and our highly detailed knowledge of the biology of these neurons, such as
knowing the identity of all genes they express, are fundamental reasons they are advantageous models for
investigating the onset of AD. Investigating the onset of AD is critical given that therapies targeting late stages
of the disease have been unsuccessful. In this administrative supplement request we propose to take
advantage of the accessibility of olfactory sensory neurons and our ongoing study of their primary function to
carefully and deeply investigate phenotypic changes in olfactory sensory neurons from two types of mouse
models of AD, one a model of early onset AD and the other a model of disease susceptibility and late onset
AD.
Status | Finished |
---|---|
Effective start/end date | 12/1/15 → 11/30/22 |
Funding
- National Institute on Deafness & Other Communications
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 1 Finished
-
In vivo patterns of receptor activation by odorants
McClintock, T. (PI)
National Institute on Deafness & Other Communications
12/1/15 → 11/30/22
Project: Research project