Integrative Proteomics and Metabololmics for Pediatric Glomerula Disease Biomarkers -- Year 5

Glomerular disease, including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and immunoglobulin A nephropathy (IgAN), often share a common clinical presentation. These chronic diseases, affecting both children and adults, produce proteinuria, hypoalbuminemia, hematuria, and/or edema, as the glomerulus is damaged by the underlying disease process. Progressive loss of kidney function often occurs over many months or years and results in substantial individual and societal burden.