Grants and Contracts Details
Description
Project Number
I01BX003643
Traumatic brain injury (TBI) resulting from combat is a prevalent head injury among Veterans.
TBI can increase the risk of developing Alzheimer''s disease (AD) by 4-fold. AD is characterized
by build-up of amyloid peptides forming plaques and hyper-phosphorylation of tau protein
forming neurofibrillary tangles, a two-fold protein aggregation process leading to
neurodegeneration and cognitive decline. It is not known how TBI increases the risk of
developing AD and how to prevent TBI-induced AD. Our research showed that even mild TBI
elicits shear forces in the brain that make particular cells secrete vesicles called exosomes.
These TBI-induced exosomes bind to amyloid peptide and tau protein and enhance their
neurotoxicity. Our goal is to interrupt TBI- induced exosome secretion to prevent or delay the
onset of AD in Veterans.
Status | Finished |
---|---|
Effective start/end date | 3/1/23 → 5/5/23 |
Funding
- Veterans Affairs: $30,312.00
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