Projects and Grants per year
Grants and Contracts Details
Description
We propose to establish a Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research
and Innovation (CPRI) at the University of Kentucky (UK) that will build on the College of Pharmacy’s key
strengths in pharmaceutical sciences and its established track record for facilitating UK research and junior
investigator career development across diverse disciplines at UK. Our contention is that the quantity and quality
of ‘translatable’ assets from basic biomedical research (sometimes referred to as ‘T0’ translation) can be
enhanced by providing investigators seamless access to fundamental pharmaceutical sciences training,
infrastructure and expertise. CPRI will address this need at UK by serving as a comprehensive multidisciplinary
center thematically-focused on early preclinical translational research and transdisciplinary innovation. As such,
CPRI will strengthen UK’s health research enterprise and synergize with the multiple UK research centers
strategically focused on basic and translational research to understand, treat and prevent the major diseases
that contribute to Kentucky’s disproportionate health challenges. The overarching goals of the COBRE are to
support junior investigator career development and to stimulate innovative, transdisciplinary research with
‘translatable’ potential. To accomplish these goals, we will: i) develop a critical mass of funded investigators with
research programs directly related to the Center''s unifying theme; ii) provide strong team-based mentoring that
includes field-specific, early career, pharmaceutical science and clinical pharmacist mentors, iii) recruit new
investigators to the Center through pilot project grant support leveraged by institutional funds, iv) create new
synergies and collaborations via crucial links to established research centers and colleges at UK, including
existing COBREs; and v) facilitate the discovery, validation and advancement of UK ''translatable'' assets. Main
COBRE deliverables include an expansion of the pool and diversity of UK scientists engaged in collaborative
translational research, a growing community of UK scientists well-positioned to advance preclinical assets, a
corresponding increase in UK’s preclinical asset pipeline, and a new conduit to stimulate interactions and
engagement of investigators from diverse scientific backgrounds. Within this context, the COBRE will initially
support four outstanding junior investigators working in three therapeutic areas; namely, cancer, infectious
disease and cardiovascular disease.
Status | Finished |
---|---|
Effective start/end date | 3/1/20 → 3/31/24 |
Funding
- National Institute of General Medical Sciences
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Projects
- 1 Active
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COBRE in Pharmaceutical Research and Innovation
Thorson, J., Helmy, Y. A., Jaramillo, A., She, Q., Adams, V., Alam, M., Awuah, S., Bardo, M., Bauer, B., Burgess, D., Czuba, L., Daugherty, A., Dwoskin, L., Feola, D., Garneau-Tsodikova, S., Gensel, J., Glazer, E., Grady, M., Graf, G., Kapur, N., Kolesar, J., Korotkov, K., Korotkova, N., Leggas, M., Mahmoud, K. A., McLaurin, K., Messaoudi Powers, I., Nikolajczyk, B., Ortinski, P., Pack, D., Park, J., Prisinzano, T., Richards, C., Rohr, J., Sen, P., Shaffer, C., Stevenson, B., Sturgill, J., Sviripa, V., Tidgewell, K., Tiruvannamalai Annam, R., Turner, J., Van Lanen, S., Venditto, V., Watt, D., Webb, N. & Zhan, C.
National Institute of General Medical Sciences
3/1/20 → 1/31/25
Project: Research project