Grants and Contracts Details
Description
The opioid crisis continues to ravage US communities with overdose deaths at an all-time high. Women are
disproportionately affected by the opioid crisis due to increased pain sensitivity, physician prescribing
practices, and self-medication, as well as a faster trajectory from opioid exposure to the development of opioid
use disorder (OUD). The opioid overdose death rate among women has risen 583% since 1999, a rate
considerably higher than men (404%). However, research on approaches to increase initiation of life-saving
medications for opioid use disorder (MOUD) among women is limited. The University of Kentucky proposes to
establish the Women’s Clinical Research Center as part of the NIDA Justice Community Opioid Innovation
Network (W-JCOIN). The overall goal of the W-JCOIN is to increase initiation and maintenance of MOUD
among high-risk justice-involved women in the transition from jail to the community to reduce opioid relapse
and overdose. As part of this NIH collaborative network, the W-JCOIN will lead a type 1 effectiveness and
implementation hybrid trial to examine an innovative MOUD pre-treatment model using telehealth (alone and in
combination with peer navigators) for justice-involved women in transition from jail to the community in 6
experimental and 3 comparison (Services as Usual-SAU) sites. The following aims guide the study: (1)
Compare the effectiveness of MOUD Pre-Treatment Telehealth (alone versus in combination with Peer
Navigators) to increase MOUD initiation and maintenance among high-risk, justice-involved women in the
community after release relative to services as usual (SAU). (2) Estimate the incremental cost and cost
effectiveness of MOUD Pre-Treatment Telehealth (alone and in combination with Peer Navigators) relative to
SAU for high-risk justice involved women with OUD in achieving desired changes in clinical, public health, and
public safety outcomes over one-year post-release. (3) Examine changes over time in key implementation
constructs hypothesized by the EPIS framework to influence successful innovation implementation. This
application is supported by an experienced team of NIH funded investigators who are well-positioned to be active
members of the JCOIN network to rapidly conduct studies on quality care for OUD, with special focus on
underserved and understudied justice-involved women. The KY W-JCOIN has the potential for significant impact
on the OUD treatment field by contributing empirical evidence on the effectiveness and implementation of
innovative technologies to increase initiation and utilization of life-saving medications during a critical, high-risk
time of community re-entry among vulnerable, justice-involved women in both urban and non-urban communities.
The long-term goal of this research is to increase the capacity for the justice system to respond to the opioid
crisis through increased access to treatment to reduce opioid relapse and overdose.
Status | Finished |
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Effective start/end date | 7/15/19 → 4/30/20 |
Funding
- National Institute on Drug Abuse: $1,733,020.00
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