Projects and Grants per year
Grants and Contracts Details
Description
Abstract
Campylobacter is the largest cause of bacterial food poisoning in humans globally, with poultry being the
most common source of human campylobacteriosis. Currently, there are no effective therapies to prevent
Campylobacter infection in poultry or humans. The routine use of broad-spectrum antibiotics for disease
management and growth promotion on farms has resulted in an increase in antibiotic-resistant
Campylobacter. As a result, developing alternatives to antibiotics is crucial for controlling the spread of
antibiotic-resistant Campylobacter while ensuring food safety. My long-term research and training goal is
to become an independent scientist in the field of combating antimicrobial-resistant (AMR) infectious
pathogens. Innovative studies carried out during my postdoctoral training demonstrated that probiotic E.
coli Nissle 1917 (EcN) restricted Campylobacter growth while modulating intestinal immunity and gut
barrier function in chickens. This project will elucidate how this probiotic mediates its action against C.
jejuni. The outcome of this study will lead to the development of novel approaches to reducing the
emergence of antibiotic-resistant Campylobacter. This award will enable me to advance my knowledge
and skills in omics analysis and the use/handling of 3D human intestinal stem cell organoids as a new
model to test drugs. Furthermore, it will provide me with the protected time and mentorship to develop
independent research in the control of antimicrobial-resistant infections. I will commit 75% effort to
Career Development and Research supported by this award.
Status | Finished |
---|---|
Effective start/end date | 2/1/24 → 6/30/24 |
Funding
- National Center for Advancing Translational Sciences
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Projects
- 1 Finished
-
Kentucky Center for Clinical and Translational Science - Institutional Career Development Core
Kelly, T., Barry-Hundeyin, M., Curry, T., DiPaola, R., Evers, B. M., Giannone, P., Guy, R. K., Helmy, Y. A., Jicha, G., Kern, P., King, V., Lephart, S., Liu, J., Talbert, J., Trout, A., Williams, L., Arnett, D., Duncan, M., Heath, E., Lacy Leigh, M., McLouth, L., Roberts, J., Samaan, M. & Supinski, G.
National Center for Advancing Translational Sciences
8/15/16 → 6/30/24
Project: Research project