KL2 scope - Probiotics-Derived Bioactive Molecules as Alternatives to Antibiotics to Mitigate Antibiotic-resistant Campylobacter Infections in Humans

Grants and Contracts Details

Description

Abstract Campylobacter is the largest cause of bacterial food poisoning in humans globally, with poultry being the most common source of human campylobacteriosis. Currently, there are no effective therapies to prevent Campylobacter infection in poultry or humans. The routine use of broad-spectrum antibiotics for disease management and growth promotion on farms has resulted in an increase in antibiotic-resistant Campylobacter. As a result, developing alternatives to antibiotics is crucial for controlling the spread of antibiotic-resistant Campylobacter while ensuring food safety. My long-term research and training goal is to become an independent scientist in the field of combating antimicrobial-resistant (AMR) infectious pathogens. Innovative studies carried out during my postdoctoral training demonstrated that probiotic E. coli Nissle 1917 (EcN) restricted Campylobacter growth while modulating intestinal immunity and gut barrier function in chickens. This project will elucidate how this probiotic mediates its action against C. jejuni. The outcome of this study will lead to the development of novel approaches to reducing the emergence of antibiotic-resistant Campylobacter. This award will enable me to advance my knowledge and skills in omics analysis and the use/handling of 3D human intestinal stem cell organoids as a new model to test drugs. Furthermore, it will provide me with the protected time and mentorship to develop independent research in the control of antimicrobial-resistant infections. I will commit 75% effort to Career Development and Research supported by this award.
StatusActive
Effective start/end date2/1/241/31/25

Funding

  • National Center for Advancing Translational Sciences

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