Grants and Contracts Details
Description
Potentially hazardous concentrations of the metal aluminum (AI) are present as a contaminant
10 solutions used for intravenous feeding. We are developing a flow-through filter device
containing a chelator (ligand) that is immobilized on small polymer beads (resin). This device
will remove the Al from the contaminated small volume parenteral (SVP) solution as it flows
from its storage vial through the filter into the bag containing the final intravenous feeding
solution (total parenteral nutrition [TPN] admixture solution). TPN solutions are given to
neonates in the intensive care unit of hospitals. Several toxic metals (AI, arsenic, chromium &
manganese) can be contaminants of the SVP solutions added to prepare the TPN solution, but Al
is the only metal for which the FDA has implemented a labeling requirement. Al has the potential
to cause toxicity to neonates and other patients. The toxic effects include impainnent of cognitive
development and generalized osteomalacia (rickets). We have synthesized some novel chelators
and immobilized some of them on a resin. Although effective to remove Al from some solutions,
we need to modify the chemistry to improve these immobilized chelators to be able to rapidly and
effectively remove Al from calcium gluconate and phosphate solutions, the primary SVP
contributors to Al in TPN solutions. That work is proposed in a STTR submission. Additional
potential applications of this technology are to remove contaminating Al from fluids given to
dialysis patients and from TPN and intravenous calcium solutions given to adults, and to remove
Al from soy-based infant fonnula. This technology could be applied to the removal of other
metals from solutions. The present application requests funds to contract for a market analysis, to
be conducted by Giles & Associates Consultancy, Inc. and to begin to develop a business plan for
the company, ALKYMOS, Inc., we established to advance this technology
Status | Finished |
---|---|
Effective start/end date | 4/1/07 → 12/31/08 |
Funding
- KY Science and Technology Co Inc: $43,997.00
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