Grants and Contracts Details
Description
The advanced analysis of pharmaceutical compounds in the solid state is very complex.
In particular, testing methods such as solid-state nuclear magnetic resonance (SSNMR)
spectroscopy require extremely expensive instruments (>$500,000) and have a very low
throughput. Despite the low throughput and expensive instrumentation, SSNMR may be
the only technique capable of analyzing the compound in a tablet. Our goal is to
increase the throughput of SSNMR experiments severalfold. To accomplish this, we
have previously developed a SSNMR probe that allows more than one sample to be
analyzed at the same time, thereby increasing throughput by a factor of four. A
significant downside of that probe was that it had to continuously move inside the NMR
magnet. In this proposal, we describe an NMR probe that can run up to four samples
simultaneously without the probe moving in the magnet. From a practical standpoint,
this is equivalent to having four NMR spectrometers running at the same time, but
without the complexity of operating and maintaining four separate instruments. To test
our concept, we have constructed a two-module prototype of the SSNMR probe.
Testing of the probe showed that it has equivalent performance to a traditional SSNMR
probe, but with complete radio-frequency isolation between the two probes, which is
critical to ensure performance. We have identified two potential routes to commercialize
thistechnology, both of which have immediate potential. We have also identified
companies that are interested in licensing thistechnology once it has been
commercialized
Status | Finished |
---|---|
Effective start/end date | 1/1/16 → 12/31/17 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.