Grants and Contracts Details
Description
Abstract
While it is generally recognized that many genetic and environmental factors contribute to
Alzheimer''s disease (AD), current research efforts treat AD as a single disease. The extent to
which heterogeneity among AD cases hinders our capacity to understand its etiology remains
unclear. Therefore, there exists a critical need to examine genetic and phenotypic differences
among AD cases to identify individuals with fundamentally different etiologies. Our overall
objective is to evaluate etiological differences in AD cases and identify subtypes of the disease
that have different health trajectories. We will characterize etiologically distinct subtypes of AD
cases by evaluating health outcomes within and between subtypes. Our central hypothesis is that
combinations of biomarkers and genetics significantly differ between individuals with AD, allowing
for subtype classification. The rationale underlying this proposal is that AD is classified on a
spectrum of neurodegeneration, and some individuals experience faster cognitive decline.
Status | Finished |
---|---|
Effective start/end date | 3/1/21 → 8/31/22 |
Funding
- BrightFocus Foundation: $157,436.00
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