Grants and Contracts Details
Description
SCOPE OF WORK
University of Kentucky Research Foundation
Leveraging senotherapeutic properties of metformin to improve collagen remodeling during muscle regrowth in
older adults
As a co-investigator in this proposal (University of Utah, PI: Micah Drummond, PhD), I will aid in the design,
collection, interpretation and analysis of experimental data. I will leverage my expertise in the in vitro culture of
primary fibrogenic/adipogenic progenitor cells (FAPs) as well as second harmonic generation and polarized
light microscopy to determine collagen architecture. I will oversee in vitro experiments as well as imaging of
human muscle biopsies. My lab will collect data from these experiments that we will share with the PI. I will
also aid in the analysis and interpretation of digital microscope images, participating in quantification of
collagen and tissue resident stem cells. I will participate in monthly Zoom-based investigator meetings and
generation of manuscripts. My contributions with advanced imaging of muscle collagen architecture and FAPs
will enable us to define specific cellular and molecular effectors underlying metformin treatment during
recovery following immobilization. Identification of these biologic mechanisms is needed to delineate the
mechanism(s) of action of metformin on skeletal muscle adaptation during reloading to help validate this novel
therapeutic intervention to speed recovery of aged muscle.
Status | Active |
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Effective start/end date | 6/1/24 → 5/31/29 |
Funding
- University of Utah: $139,759.00
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