Longitudinal Evaluation of Amyloid Risk and Neurodegeneration NIH the LEARN Study

The A4 LEARN Observational Study is a companion study to the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s disease (A4) Trial. This Study shall be conducted according to the terms of this Subaward and the Protocol referenced above and incorporated herein by reference and which fully details the clinical research activities and responsibilities to be undertaken. The Institution agrees to conduct the trial pursuant to the respective Protocol and to accurately complete and promptly submit electronic case report forms (“eCRFs”) during the period specified for the conduct of the Study. Institution agrees to conduct this Study in strict accordance with the Protocol, which is incorporated by reference herein, (as it may be amended from time to time by the Company and/or UCSD), all applicable guidelines relevant to the conduct of clinical protocols, including, but not limited to the Federal Food, Drug and Cosmetic Act and regulations of the FDA, HIPAA, conditions imposed by the Institution’s IRB and the written instructions of UCSD relative to the administration of the Protocol. The Parties agree to comply with and to conduct the Study in accordance with all applicable federal, state and local laws and regulations.