Lysine-Specific Demethylase-1 Essential for Snail-Mediated Basal-Like Breast Cancer Metastasis

Grants and Contracts Details


The central hypothesis of our proposal is that synergistic cooperation between the intrinsic interactions of Snail with LSD1 is crucial for basil-like breast cancer invasion and metastasis. The objective of this proposal is to dissct the epigenetic regulation of EMT by the Snail-LSD1 complex and explore the therapeutic potential for inihbiting this complex to prevent basal-like breast cancer mestastasis.
Effective start/end date1/1/1012/31/12


  • American Cancer Society


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