Lysine-Specific Demethylase-1 Essential for Snail-Mediated Basal-Like Breast Cancer Metastasis

Grants and Contracts Details

Description

The central hypothesis of our proposal is that synergistic cooperation between the intrinsic interactions of Snail with LSD1 is crucial for basil-like breast cancer invasion and metastasis. The objective of this proposal is to dissct the epigenetic regulation of EMT by the Snail-LSD1 complex and explore the therapeutic potential for inihbiting this complex to prevent basal-like breast cancer mestastasis.
StatusFinished
Effective start/end date1/1/1012/31/12

Funding

  • American Cancer Society

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