Grants and Contracts Details
Description
To date, caloric restriction has shown itself to be the most reproducible and promising intervention to
improve cancer outcomes in laboratory animals. An intense and expanding area of research is focused on
discovering easily achievable interventions that can have long-lasting positive effects. This proposal will
explore maternal exercise during pregnancy as a potential short-term intervention that can provide a lifetime of
benefits for the next generation. In a small pilot study in mice, offspring born to exercised dams had improved
glucose regulation and enhanced stress protection compared to offspring born to sedentary dams. These
preliminary findings contribute to the hypothesis that maternal exercise during pregnancy and nursing
protects mature offspring against chemical carcinogens because of increased activities of antioxidant
enzymes. The first aim is designed to test whether maternal exercise during pregnancy is a realistic
intervention that can protect mature offspring from chemical carcinogens. The second aim will look to elucidate
the role of the stress-induced transcription factor, nuclear factor erythroid-2 related factor 2, as a potential
mechanism for long-lasting protection by perinatal exercise. These studies will provide important information
on the potential positive impact maternal exercise may have on offspring cancer protection.
Status | Finished |
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Effective start/end date | 7/9/12 → 6/30/15 |
Funding
- National Cancer Institute: $144,045.00
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