Mechanism and Approach to Inactivate Mutant KRAS of Lung Metastatic Colon Cancer by RNA-ligand-displaying Exosome to Co-deliver dCas9--gRNA Ribonucleoprotein Complex and KRAS siRNA

Pharmacology, Toxicology and Pharmaceutical Science

1. Metastatic Colon Cancer 100%
2. Small Interfering RNA 100%
3. Ribonucleoprotein 100%
4. Nanoparticle 100%
5. Liver Metastasis 66%
6. Lung Metastasis 66%
7. Antiinfective Agent 33%
8. Cancer Survival 33%