Mechanisms for activation of beige adipose tissue in humans; Supplement.

Grants and Contracts Details

Description

ABSTRACT This proposal is a supplement to “Mechanisms for Activation of Beige Adipose Tissue in Humans”, R01 DK124626 in response to NOT-DK-22-017, entitled: “Impact of COVID-19 on diabetes incidence and severity in the United States and Kentucky” Diabetes, obesity and other metabolic diseases are risk factors for the development of severe COVID-19 infections. In addition to being a risk factor, however, there is mounting evidence that COVID-19 is causing new incident diabetes, and there have been a number of such descriptions in both children and adults. There are a number of potential mechanisms for incident diabetes following COVID-19, including the increased inflammatory burden, the unmasking of autoimmunity, and the treatment of COVID-19, which often involves steroids. In addition, the post-COVID-19 syndrome may result in changes in physical activity and diet. All of these effects may be more pronounced in a population that is historically underserved, where obesity and diabetes are more prevalent and where vaccine uptake is lower. This supplement assembles a team of Endocrinologists, Pulmonary intensivists, Informaticians, Epidemiologists and Statisticians to examine incident diabetes in a number of different data sets, but with emphasis on the population of Kentucky. Our overall hypothesis is that new onset diabetes will be highest in areas of Kentucky with the highest health disparities, especially with regards to obesity and metabolic risk factors. In addition, we hypothesize that low vaccine uptake in local communities will be associated with a high risk of developing diabetes. To address these hypotheses, we propose the following Specific Aims. 1. Compare the incidence of new onset diabetes during the COVID-19 outbreaks of 2020-2022 to pre-COVID years of 2017-2019 among large commercially insured population datasets (MarketScan) and economically disadvantaged populations (Kentucky Medicaid claims). 2. Using our Electronic Health Records database records, it is proposed to conduct a deep dive into the cases of incident diabetes to determine the key factors (ie, age, BMI, demographics, vaccination status and overall health) that are associated with diabetes severity, type of incident diabetes, and the timing of onset of diabetes following COVID-19 disease. Clinical relevance. Current literature describes an association between prior COVID-19 infection and diabetes, but without much more depth. This study will examine the relationship between COVID-19 and incident diabetes in two very different populations, including rural Kentucky, which has high health disparities. In addition, we will examine the effects of prior vaccination, which may lessen the severity of disease and decrease diabetes incidence.
StatusActive
Effective start/end date12/1/2011/30/26

Funding

  • National Institute Diabetes & Digestive & Kidney

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